منابع مشابه
Inhibition of Glutathione Synthesis
A preliminary account of this work was presented at the 66th Annual Meeting of the Federation of American Societies for Experimental Biology, April 1982. Dr. Nathan is an Irma T. Hirschl Career Scientist. Address reprint requests to Dr. Arrick. Received for publication 23 June 1982 and in revised form 18 October 1982. with BSO alone results in near-complete GSH depletion without loss of cell vi...
متن کاملEnzymatic synthesis of glutathione.
The formation of glutathione in liver slices, in liver homogenates, and in extracts of acetone-dried pigeon liver and the effect of adenosinetriphosphate on this reaction have previously been demonstrated in this laboratory (l-3). In the present report, the synthesis of glutathione which is catalyzed by soluble liver enzymes is described in greater detail. The reaction occurs anaerobically when...
متن کاملGlutathione-dependent Synthesis of Deoxyribonucleotides
This reaction in vitro requires the combined function of three pure Escherichia coli proteins, namely the Bl and B2 subunits of ribonucleotide reductase and glutaredoxin. The stoichiometry was demonstrated by determinations of the products r3H]dCDP and GSSG. The standard assay couples oxidation of NADPH to the reduction of GSSG by glutathione reductase. The apparent K,,, value of glutaredoxin w...
متن کاملPolyphenols and glutathione synthesis regulation.
Polyphenols in food plants are a versatile group of phytochemicals with many potentially beneficial activities in terms of disease prevention. In vitro cell culture experiments have shown that polyphenols possess antioxidant properties, and it is thought that these activities account for disease-preventing effects of diets high in polyphenols. However, polyphenols may be regarded as xenobiotics...
متن کاملImpaired Glutathione Synthesis in Neurodegeneration
Glutathione (GSH) was discovered in yeast cells in 1888. Studies of GSH in mammalian cells before the 1980s focused exclusively on its function for the detoxication of xenobiotics or for drug metabolism in the liver, in which GSH is present at its highest concentration in the body. Increasing evidence has demonstrated other important roles of GSH in the brain, not only for the detoxication of x...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1935
ISSN: 0306-3283
DOI: 10.1042/bj0291602